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Subclinical inflammation and soleus muscle intramyocellular lipids in healthy Asian Indian males
Author(s) -
Sinha Sanjeev,
Rathi Manish,
Misra Anoop,
Kumar Virendra,
Kumar Mahesh,
Jagannathan N. R.,
Pandey Ravindra Mohan,
Dwivedi Manjari,
Luthra Kalpana
Publication year - 2005
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.2005.02353.x
Subject(s) - medicine , endocrinology , insulin resistance , waist , body mass index , abdominal obesity , insulin , obesity
Summary Objectives The relationship between C‐reactive protein (CRP), a marker of subclinical inflammation, and intramyocellular lipid (IMCL) content, a novel correlate of insulin resistance, has not previously been investigated. Method and design We estimated IMCL content in soleus muscle in 30 healthy Asian Indian males using proton magnetic resonance spectroscopy ( 1 H MRS), and correlated it with body mass index (BMI), measures of abdominal obesity, percentage of body fat (%BF), serum lipoproteins, fasting and post‐oral glucose load serum insulin levels and other surrogate markers of insulin resistance. Results Soleus muscle IMCL content was significantly correlated with age (ρ = 0·64, P < 0·001), BMI (ρ = 0·41, P < 0·05), %BF (ρ = 0·53, P ≤ 0·01), waist circumference (ρ = 0·45, P < 0·05) and waist‐to‐hip circumference ratio (ρ = 0·58, P < 0·01) but did not correlate significantly with insulin resistance measured by the homeostasis model assessment (HOMA‐IR) or CRP levels. CRP levels did not correlate with the HOMA‐IR value. Conclusions Soleus muscle IMCL content correlated significantly with measures of generalized and abdominal obesity but not with insulin sensitivity or CRP levels in healthy Asian Indian males. Studies are needed in other ethnic groups to corroborate these data.