Premium
Relationship between fasting serum glucose, age, body mass index and serum 25 hydroxyvitamin D in postmenopausal women
Author(s) -
Need Allan G.,
O'Loughlin Peter D.,
Horowitz Michael,
Nordin B. E. Christopher
Publication year - 2005
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.2005.02288.x
Subject(s) - medicine , endocrinology , vitamin d and neurology , body mass index , outpatient clinic , vitamin d deficiency , diabetes mellitus , creatinine , type 2 diabetes , calcifediol
Summary Objective Because it has been reported that vitamin D, given to mother or infant, can prevent type I diabetes in children, that diabetes is more common in adults with low serum vitamin D and that insulin secretion and action are related to vitamin D levels in healthy young adults we examined the relationship between serum vitamin D metabolites and fasting serum glucose in patients attending our outpatient clinics. Design Retrospective examination of convenience sample of postmenopausal women attending our osteoporosis clinics. Patients A total of 753 postmenopausal women attending a university hospital outpatient clinic and not on any treatment known to affect glucose metabolism. Measurements Body weight and height, serum 25‐hydroxyvitamin D [25(OH)D], serum 1,25‐dihydroxyvitamin D [1,25(OH) 2 D], serum PTH and fasting serum glucose. Results On simple correlation fasting serum glucose was a positive function of age ( P < 0·05), weight ( P < 0·001) and body mass index (BMI) ( P < 0·001) and a negative function of serum 25(OH)D ( P < 0·001), but it was not significantly related to either serum 1,25(OH) 2 D, PTH or creatinine. When fasting serum glucose was regressed simultaneously on age, BMI and 25(OH)D, glucose was still an inverse function of 25(OH)D ( P = 0·006). Conclusions Fasting serum glucose increased as 25(OH)D levels fell throughout the range of serum 25(OH)D measured but the greatest increase was observed in those with 25(OH)D below 40 nmol/l.