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Correlation between severity of thyroid dysfunction and renal function
Author(s) -
Den Hollander Jan G.,
Wulkan Remi W.,
Mantel Mart J.,
Berghout Arie
Publication year - 2005
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.2005.02236.x
Subject(s) - renal function , medicine , endocrinology , creatinine , thyroid function , thyroid , hormone , kidney disease , kidney , urology
Summary Objective Renal function is profoundly influenced by thyroid status; however, this has not been studied in detail in human subjects. The purpose of the present study was to determine the relationship between renal function and thyroid status before and after treatment for hypothyroidism and hyperthyroidism, respectively. Design and patients In 37 consecutive hypothyroid and 14 hyperthyroid patients renal function as measured by plasma creatinine and glomerular filtration rate (GFR) [based on the modification of diet in renal disease (MDRD) formula] was determined before treatment and after regaining euthyroidism. Results Renal function improved significantly during treatment of hypothyroidism and decreased during treatment of hyperthyroidism. There was a strong correlation between the change in thyroid status determined as the ratio log 10 (fT4 post‐treatment/fT4 pretreatment) and the change in renal function as a result of therapy expressed as serum creatinine ( r 2 = 0·81, P < 0·0001) and estimated GFR (0·69, P < 0·0001). Conclusion The kidney is an important target of thyroid hormone action.