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Apolipoprotein E phenotype affects the malondialdehyde‐modified LDL concentration and forearm endothelial function in postmenopausal women
Author(s) -
Tsuda Mikio,
Sanada Mitsuhiro,
Higashi Yukihito,
Hara Yoshiko,
Kodama Ichiro,
Chayama Kazuaki,
Yoshizumi Masao,
Ohama Koso
Publication year - 2004
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.2004.02145.x
Subject(s) - medicine , endocrinology , hyperaemia , malondialdehyde , lipoprotein , forearm , chemistry , apolipoprotein b , cholesterol , blood flow , oxidative stress , surgery
Summary objective We investigated whether the apolipoprotein E (apo E) phenotype affects the serum concentration of malondialdehyde‐modified low‐density lipoprotein (MDA‐LDL) or forearm endothelial function in postmenopausal women. patients and measurements Individuals were divided into three groups according to their apo E phenotype: E2 (E2/2 and E2/3, n = 12); E3 (E3/3, n = 71); and E4 (E3/4 and E4/4, n = 27). The serum concentrations of lipids and MDA‐LDL were measured. Forearm blood flow during reactive hyperaemia and after sublingual nitroglycerin administration was measured by strain‐gauge plethysmography. results The serum concentrations of total and LDL cholesterol were significantly higher in the E4 group than in the E2 group ( P < 0·05) or in the E3 group ( P < 0·05). The serum apo B concentration was significantly higher in the E4 group than in the E2 group ( P < 0·05). The serum concentrations of high density lipoprotein (HDL) cholesterol and nitrite/nitrate were significantly lower in the E4 group than in the E2 group ( P < 0·05). Other lipid concentrations did not differ in the three groups. The serum MDA‐LDL concentration was highest in the E4 group, and was lowest in the E2 group (E2: 91·1 ± 6·9 IU/l, E3: 112·3 ± 5·9 IU/l, E4: 128·8 ± 9·9 IU/l; P < 0·05). The forearm blood flow response to reactive hyperaemia was lowest in the E4 group, and highest in the E2 group (E2: 52·2 ± 5·8 ml/min per 100 ml tissue, E3: 40·7 ± 1·7 ml/min per 100 ml tissue, E4: 33·4 ± 2·4 ml/min per 100 ml tissue; P < 0·05). The forearm blood flow changes in response to nitroglycerine were similar between all three groups. conclusions The apo E phenotype affects the serum MDA‐LDL concentration and forearm endothelial function in postmenopausal women.