Premium
Circulating immunoglobulins that inhibit the binding of follicle‐stimulating hormone to its receptor: a putative diagnostic role in resistant ovary syndrome?
Author(s) -
Chiauzzi Violeta A.,
Bussmann Leonardo,
Calvo Juan Carlos,
Sundblad Victoria,
Charreau Eduardo H.
Publication year - 2004
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.2004.02054.x
Subject(s) - follicle stimulating hormone receptor , antibody , endocrinology , receptor , medicine , ovary , follicle stimulating hormone , hormone , premature ovarian failure , biology , hormone receptor , gonadotropin , immunology , luteinizing hormone , cancer , breast cancer
objective To evaluate the presence of circulating immunoglobulins that inhibit FSH binding to its receptor (Ig‐FSHR) in patients with premature ovarian failure (POF). design Non‐randomized study. Blood sampling for determination of circulating immunoglobulins. patients Two hundred and forty‐seven patients with POF and 60 normally menstruating women (controls). measurements Circulating immunoglobulins that inhibit FSH binding to its receptor were assessed by FSH‐binding inhibition assay. results Twenty‐three out of 247 women with POF presented circulating immunoglobulins that inhibit FSH binding to its receptor. These patients had been previously diagnosed as ROS. Sixty control subjects proved negative. conclusion Determination of the presence of circulating immunoglobulins that inhibit FSH binding to its receptor could be instrumental in diagnosing the gonadotropin resistance ovary syndrome.