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Prevalence and determinants of left ventricular hypertrophy in acromegaly: impact of different methods of indexing left ventricular mass
Author(s) -
Vitale Giovanni,
Galderisi Maurizio,
Pivonello Rosario,
Spinelli Letizia,
Ciccarelli Antonio,
De Divitiis Oreste,
Lombardi Gaetano,
Colao Annamaria
Publication year - 2004
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.2004.01985.x
Subject(s) - left ventricular hypertrophy , acromegaly , medicine , body surface area , cardiology , muscle hypertrophy , endocrinology , body mass index , overweight , blood pressure , growth hormone , hormone
Summary background Left ventricular hypertrophy (LVH) is the most common cardiac abnormality in acromegaly. Left ventricular mass (LVM) is an important parameter measured to detect LVH, but the relationship with body size should be considered by correcting LVM to body surface area (BSA), height or height 2·7 . All trials concerning acromegaly have detected LVH on the basis of LVM indexed for BSA, but have been criticized for disregarding the effects of obesity. patients and measurements 97 patients with active acromegaly and a control group of 97 nonacromegalic subjects, were compared for the prevalence of LVH, calculated with different corrections of LVM for BSA, height and height 2·7 . In addition, we evaluated determinants of LVH in acromegalic group. results In controls, the prevalence of LVH, determined by correcting LVM for BSA (10·3%) was significantly lower than correcting by LVM/height (21·6%, P = 0·05) and LVM/height 2·7 (33%, P < 0·0001). Similarly, in the acromegalic population the prevalence of LVH was significantly higher when measured by LVM/height (86·6%) or LVM/height 2·7 (89·7%), than by LVM/BSA (67%) ( P = 0·002 and P < 0·0001, respectively). A lower prevalence of LVH detected by LVM/BSA than LVM/height and LVM/height 2·7 has been observed in an acromegalic overweight group, while in patients with normal weight there was no significant differences using different corrections. In acromegalic patients with disease duration of ≤ 10 years the prevalence of LVH by correcting LVM for height 2·7 was higher than when correcting for BSA. No difference in the prevalence of LVH determined by different corrections was observed in patients with disease duration > 10 years. By separate multiple regression analyses systolic blood pressure was the only independent determinant of LVM/BSA or LVM/height, while systolic blood pressure and GH levels were both predictors of LVM/height 2·7 . conclusions LVM indexed for height 2·7 appears to be the most appropriate method to identify LVH in acromegaly, particularly in overweight patients and those with shorter disease duration.