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Lymphocytic hypophysitis: unusual features of a rare disorder
Author(s) -
Jenkins P. J.,
Chew S. L.,
Lowe D. G.,
Afshar F.,
Charlesworth M.,
Besser G. M.,
Wass J. A. H.
Publication year - 1995
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1995.tb02673.x
Subject(s) - hypophysitis , medicine , acromegaly , differential diagnosis , posterior pituitary , anterior pituitary , pituitary disorder , pituitary gland , hypopituitarism , endocrinology , pathology , hormone , growth hormone
Summary OBJECTIVE Lymphocytic hypophysitis is a rare disorder which usually affects women and Is often associated with pregnancy. We reviewed our experience of this disorder In order to see whether these features were universal amongst our patients. DESIGN A retrospective review of case notes. PATIENTS Four patients with histologically proven lymphocytic hypophysitis. MEASUREMENTS Each patient had undergone full radiological and biochemical assessment of anterior and posterior pituitary function. RESULTS Only one woman presented during pregnancy, one patient was a man with coexistent active acromegaly, and one progressed over 5 years to panhypopituitarism. In one further patient, histological analysis revealed normal anterior pituitary tissue adjacent to lymphocytic follicles. CONCLUSIONS Lymphocytic hypophysitis should be considered in the differential diagnosis of any patient with a pituitary mass. We suggest that the entire removal of such a mass is warranted both for accurate diagnosis and definitive treatment.