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Autonomous hyperparathyroidism in X‐linked hypophosphataemia
Author(s) -
Knudtzon Jergen,
Halse Johan,
Monn Elrik,
Nesland Aasve,
Nordal Knut P.,
Paus Povel,
Selp Martin,
Sund Ståle,
Sedall Gunnar
Publication year - 1995
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1995.tb01863.x
Subject(s) - calcitriol , discontinuation , rickets , hypercalcaemia , medicine , hypophosphatemia , endocrinology , hyperparathyroidism , vitamin d and neurology , parathyroid hormone , calcium
Summary Four patients with familial hypophosphataemic rickets developed significant hypercalcaemia which persisted after discontinuation of vitamin D therapy. They had increased PTH levels and were operated for hyperparathyroldism at the ages of 18, 20, 24 and 45 years, respectively. Three of the patients had previously received phosphate treatment and one patient developed hyperparathyroldism 7 years after treatment with calcitriol. Histological evaluation revealed different degrees of parathyroid hyperplasia in all patients, with persistently Increased PTH and/or calcium levels after surgery. The possibility of autonomous hyperparathyroldism should be evaluated in the follow‐up of patients with X‐linked hypophosphataemic rickets.