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Calcitonin‐producing insulinoma: clinical, immunocytochemical and cytogenetical study
Author(s) -
Bugalho Maria João G. M.,
Roque Lúcia,
Sobrinho Luís G.,
Hoog Anders,
Nunes José F. Moura,
Aimeida José M. Mendes,
Leltão C. Nobre,
Santos Jorge R.,
Pereira Maria Conceičão,
Santos Maria Amparo,
Soares Jorge
Publication year - 1994
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1994.tb02539.x
Subject(s) - insulinoma , calcitonin , medicine , endocrinology , pentagastrin , insulin , secretion , gastric acid
Summary The case of a patient with a large goitre associated with hypercaicitoninaemia and fasting hypoglycaemia is reported. Pentagastrin (PG) test was negative. Repeated measurements of fasting glycaemia, insulin and C peptide established the diagnosis of insulinoma. After localization by endoscopic ultrasonography, a distal pancreatectomy was performed and a small insulinoma was recovered. Glycaemia and calcitonin (cT) became normal. The tumour cells a a strong immunoreactivity for insulin and CT. Cytogenetical evaluation of the tumour revealed a translocation t(1;9) (pl3;p22).