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Hyperthyroidism secondary to a pituitary adenoma secreting TSH, FSH, alpha‐subunit and GH
Author(s) -
Patrick A. W.,
Atkin S. L.,
MacKenzie J.,
Foy P. M.,
White M. C.,
MacFarlane I. A.
Publication year - 1994
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1994.tb02480.x
Subject(s) - endocrinology , medicine , pituitary adenoma , adenoma , hormone , secretion , pituitary gland , g alpha subunit , alpha (finance) , prolactin , anterior pituitary , in vitro , pituitary hormones , biology , protein subunit , biochemistry , construct validity , nursing , patient satisfaction , gene
Summary A 51‐year‐old man had been treated for hyperthyroidism with antithyroid drugs for 8 years. He was then found to have a large pituitary adenoma with biochemical evidence of overproduction of TSH, FSH and alpha‐subunit. Subsequent immunocytochemical and tissue culture studies confirmed secretion of these hormones. In addition, the tumour stained for GH and was capable of GH production in vitro. This combination of hormones produced by a pituitary adenoma has not been previously reported.