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Tissue‐specific modulation of insulin receptor mRNA levels in a patient with a phaeochromocytoma
Author(s) -
Leal M. A.,
Aller P.,
Torres A.,
Picardo A.,
Calle C.
Publication year - 1993
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1993.tb02418.x
Subject(s) - endocrinology , medicine , adipose tissue , insulin , insulin receptor , receptor , messenger rna , biology , in vivo , gene expression , insulin resistance , gene , biochemistry , microbiology and biotechnology
Summary We have observed that the expression of the insulin‐receptor gene is regulated in a tissue‐specific manner in a patient with a phaeochromocytoma. Our results Indicate that insulin receptor mRNA levels are decreased in adipose tissue and increased in both liver and skeletal muscle as compared with the corresponding values in the same tissues of a control patient. These findings provide the first evidence that insulin receptor mRNA levels may be modulated in vivo by high levels of catecholamines.