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Plasma IGFBP‐3 and its relationship with quantitative growth hormone secretion in short children *
Author(s) -
Phillip Moshe,
Chalew Stuart A.,
Kowarski A. Avinoam,
Stene Mark A.
Publication year - 1993
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1993.tb02389.x
Subject(s) - medicine , endocrinology , radioimmunoassay , stimulation , short stature , idiopathic short stature , growth hormone , secretion , hormone , biology
Summary OBJECTIVE We assessed the relationship between serum IGFBP‐3 levels with IGF‐I and quantitative GH secretory status in poorly growing children. DESIGN We studied the relationship between 24‐hour integrated concentration of GH, peak GH to paired sequential stimulation tests, IGF‐I and the IGFBP‐3 serum levels. PATIENTS One hundred and two children (82 males, 20 females, age 11.7±2.7 years) with short stature (height 2.6±0.7 SDS) were studied. MEASUREMENTS Quantitative GH secretory status was assessed by the 24‐hour integrated GH and by response to arginine and insulin stimulation. GH, IGFBP‐3 and IGF‐I were measured by radioimmunoassay. To adjust for age and gender, IGFBP‐3 levels were converted to SD score. RESULTS IGFBP‐3 SDS was strongly correlated with IGF‐I SDS ( r = 0 64, P <0.0001), and weakly with peak GH ( r = 0.28, P <0 0004), but not with the integrated GH concentration ( r = 0 07, P <0 46). IGFBP‐3 SDS increased with pubertal maturation ( P < 0 0001). There was no difference in mean IGFBP‐3 SDS in subgroupings of the patients based on the results of their quantitative GH tests. CONCLUSION In short children, IGFBP‐3 levels increase with puberty, are strongly correlated with IGF‐I levels, weakly correlated with peak response to GH stimulation tests, but not correlated with integrated GH. Consequently, diagnostic classifications of patients based on quantitative measurements of GH secretion and IGFBP‐3 differ.