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Protein intake during aggressive calorie restriction in obesity determines growth hormone response to growth hormone‐releasing hormone after weight loss
Author(s) -
Megia Ana,
Herranz Lucrecia,
Luna Reyes,
GómezCandela Carmen,
Pallardo Felipe,
GonzalezGancedo Pilar
Publication year - 1993
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1993.tb01777.x
Subject(s) - calorie restriction , medicine , endocrinology , weight loss , very low calorie diet , calorie , hormone , obesity , low calorie diet , insulin
Summary OBJECTIVE We evaluated the influence of two types of calorie restriction, total fast or very low calorie diet, on GH responsiveness to GHRH in severely obese patients. DESIGN Twenty patients with massive obesity underwent one of two types of calorie restriction, total fast (10 patients) or very low calorie diet (10 patients). MEASUREMENTS Fasting GH, IGF‐I, glucose, insulin and GH secretion after GHRH (100 ug i.v.) were assessed in all patients before and after diet therapy. RESULTS Both types of diet produced similar weight reduction (total fast, 5.6 ± 1.6 kg/m 2 vs very low calorie diet, 5.6 ± 1.5 kg/m 2 mean ± SD). A significant increase in the integrated GH secretion was observed after weight‐loss with very low calorie diet (17 ± 9 vs27 ± 12mU/l min; P < 0.05). However, no change was found in GH response after weight loss with total fast (13 ± 5 vs 15 ± 7 μ/l min). Glucose, insulin and IGF‐I levels showed a significant decrease with weight reduction which was similar for both groups. CONCLUSION These findings suggest that the type of dietary manipulation during calorie restriction in obese patients may influence the changes in GH response to GHRH after weight loss.