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Insulin secretion and insulin‐like growth factor‐I levels in active and controlled acromegaly
Author(s) -
Hopkins K. D.,
Holdaway I. M.
Publication year - 1992
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1992.tb02902.x
Subject(s) - acromegaly , medicine , endocrinology , insulin , insulin like growth factor , secretion , growth factor , growth hormone , hormone , receptor
Summary objective We examined the contributions of growth hormone (GH) and Insulin‐like growth factor‐I (IGF‐I) to Insulin sensitivity and beta‐cell function in acromegaly. design A cross‐sectional study was used with continuous Infusion of glucose with model assessment todetermine Insulin sensitivity and beta‐cell function. patients Ten patients with active acromegaly, seven with controlled disease and 22 normal Individuals werestudied. measurements Glucose and insulin levels were measured fasting and at the end of the one‐hour glucose Infusion to calculate insulin sensitivity and beta‐cell function. Random GH and IGF‐I were recorded. Most patients had values of GH taken after a 100‐g oral glucose tolerance test and K values from Intravenous glucosetolerance tests. results Patients with active acromegaly had significantly decreased Insulin sensitivity compared to thenormal population ( P < 0·001), while those with controlled disease did not. There was a significant negative correlation between IGF‐I and insulin sensitivity In those with active disease ( P < 0·05). Beta‐cell function in both active and controlled patient groups was elevated compared tothe normal population ( P < 0·05, P < 0·01 respectively) and this was significantly related to IGF‐I in the active group ( P < 0·05). GH levels did not correlate with fasting Insulin, glucose, Insulin sensitivity or beta‐cell function In either group. conclusions Patients with active acromegaly have decreased insulin sensitivity and Increased beta‐cell function that are significantly related to IGF‐I but not GH levels. When the disease is controlled, beta‐cell function remains elevated but Insulin sensitivity Improves.