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Failure to find an association of blood group P 1 with thyroid‐associated ophthalmopathy
Author(s) -
Weetman A. P.,
Poole Joyce
Publication year - 1992
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1992.tb02353.x
Subject(s) - medicine , graves' ophthalmopathy , graves' disease , eye disease , thyroid , prospective cohort study , relative risk , endocrinology , disease , risk factor , gastroenterology , surgery , confidence interval
OBJECTIVE Genetic factors have been proposed to account for the development of ophthalmopathy in a proportion of patients with Graves' disease. The aim of this study was to confirm the previously reported association between blood group P 1 and thyroid‐associated ophthalmopathy. DESIGN A prospective study of sequential Caucasian patients. PATIENTS We studied 169 patients with Graves' disease, 84 of whom had grade 3,4 or 6 ophthalmopathy and 85 had no eye signs. MEASUREMENTS Blood group P 1 was measured by a standard serologlcal technique. RESULTS The frequency of the P 1 blood group was 74.1% in the patients without eye signs and 77.4% in those with ophthalmopathy ( X 2 = 025, P >0.1). By Woolf's method there was no significant difference in the test for heterogeneity of estimates between the present and the previously reported series of Graves' patients. Combining the results ( n = 279), the pooled relative risk for ophthalmopathy with blood group P 1 did not differ significantly from 10( X 2 = 233, P >0.1). CONCLUSIONS The presence of blood group P 1 In patients with Graves' disease does not appear to be associated with an increased risk of developing thyroid‐associated ophthalmopathy.