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Pituitary histology in Cushing's disease
Author(s) -
Kruse Anders,
Klinken Lelf,
Holck Susanna,
Lindholm Jörgen
Publication year - 1992
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1992.tb02319.x
Subject(s) - hypophysectomy , medicine , pituitary adenoma , histology , cushing's disease , adenoma , pituitary gland , neurosurgery , lesion , pathology , disease , pituitary disease , surgery , hormone
OBJECTIVE We assessed pituitary histology in patients with Cushing's disease. DESIGN Systematic histological assessment of pituitary tissue removed at surgery. PATIENTS Thirty‐six consecutive patients cured from Cushing's disease by transsphenoidal neurosurgery. MEASUREMENTS Microscopical examination of all available tissue removed at operation. RESULTS After selective removal of tissue supposed to represent an adenoma in 25 patients this could be histologically verified in 18. In the 11 patients who had undergone a total hypophysectomy an adenoma could be demonstrated in three patients only, despite a systematic search of the entire pituitary gland. Only in 21 of the 36 cured patients (58%) could an adenoma be verified. CONCLUSIONS Combining the present results with previous reports there is strong reason to believe that in some patients with Cushing's disease no histological lesion in the pituitary is verifiable.