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Hormonal management of prostate cancer
Author(s) -
Wasan Harpreet S.,
Waxman Jonathan
Publication year - 1992
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1992.tb01476.x
Subject(s) - prostate cancer , blockade , androgen , prostate , medicine , endocrine system , hormone , clinical trial , disease , oncology , cancer , endocrinology , bioinformatics , biology , receptor
Summary In advanced disease, androgen deprivation remains the usual treatment. The completion of current trials is awaited to confirm whether total androgen blockade will prolong survival. To make further advances in treatment the fundamental biology of the prostate cell, benign or malignant, and its relationship to endocrine manipulation, must be understood. This may then lead to an understanding of clonal escape mechanisms in transformed cells and the clinical correlate of escape, relapse.