Efficacy of a new long‐acting injectable form of bromocriptine in hyperprolactinaemic patients

SUMMARY objective The objective of this study was to assess the relationship of different doses of a long‐acting bromocriptine preparation (Pariodel LAR) to the degree and duration of PRL suppression. We also measured circulating bromocriptine levels and altered tolerability of the drug design A double‐blind randomized study of three different doses 25, 50 and 100 mg of Pariodel LAR patients Twenty‐one female patients (seven patients/dose) with both tumoral and non‐tumoral hyperproiactinaemia measurements After a single injection of Parlodel LAR 25, 50 or 100 mg, serum PRL and plasma bromocrlptlne levels were assessed during a follow‐up of 60 days together with changes in clinical symptoms and signs of hyperproiactinaemia results Serum PRL levels normailzed In 19 of 21 patients. The suppression of PRL secretion lasted 28 days in four of seven patients treated with either 25 or 50 mg Parlodei LAR and in five of seven patients who received Parlodel LAR 100 mg. In five of seven patients treated with the 100 mg dose, serum PRL levels were still within the normal range on day 60. Plasma bromocriptine levels remained therapeutically active for 28 days in all three groups. On day 60 they were within the therapeutic range only in the 100 mg group. Clinical data show a rapid disappearance of symptoms and signs of hyperprolactlnaemla. Adverse events were mostly mild and transient conclusions These data support the excellent efficacy and good tolerability of Pariodel LAR in patients with hyperproiactinaemia