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The effects of the specific serotonin antagonist ICI 169, 369 on the pituitary hormone response to insulin‐induced hypoglycaemia in humans
Author(s) -
Thompson C. J.,
Jones I. R.,
Walker M.,
Baylis P. H.,
KendallTaylor P.
Publication year - 1992
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1992.tb01438.x
Subject(s) - endocrinology , medicine , prolactin , insulin , placebo , hormone , anterior pituitary , vasopressin , serotonin , adrenocorticotropic hormone , hydrocortisone , antagonist , receptor , alternative medicine , pathology
SUMMARY objective To examine the role of serotonin in pitultary hormone release by studying the effect of a specific 5HT 2 receptor antagonist, ICI 169,369, on the ACTH, prolactin, growth hormone and AVP response to insulin‐Induced hypoglycaemia in healthy humans. design A double‐blind, within‐subject trial using a cross‐over design to compare the effect of placebo with two doses of ICI 169,369 on pituitary hormone responses to insulin‐induced hypoglycaemia patients Ten healthy subjects were studied In the low‐dose (30 mg × 2) limb and 11 healthy volunteers in the high‐dose (80 mg × 2) limb measurements Plasma concentrations of prolactin, growth hormone, ACTH, cortisol and AVP, and blood glucose results In the low‐dose study, pretreatment with 30 mg ICI 169,369, 10 and 2 hours before the study, had no effect on the fall in blood glucose or the rise in plasma ACTH, prolactin, growth hormone, AVP or plasma cortisol following insulin injection, when compared with placebo. In the high‐dose study the effect of a higher dose (80 mg) of ICI 169,369 on the pituitary hormone response to hypoglycaemia was compared with that of placebo. Although the fall in blood glucose was similar following drug (4·3±0·1 to 1·5±0·5 mmol/l, mean ± SEM, P > 0·001) and placebo (4·3±0·1 to 1·4±0·4 mmol/l, P > 0·001), the rise in plasma AVP was lower ( P > 0·05) following pretreatment with drug (0·5±0·2 to 2·1±0·6 pmol/l, P > 0·05) than with placebo (0·7±0·2 to 3·4±0·9 pmol/l, P > 0·01). conclusions The ACTH, prolactin, growth hormone and cortisol responses were unaffected by ICI 169,369. The data are compatible with an Inhibitory effect of the serotonin antagonist ICI 169,369 on the AVP, but not the ACTH, proiactin or growth hormons to insulln‐induced hypoglycasmia in humans