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Long‐term follow‐up of hypothalamic‐pituitary function in patients with transsphenoidal pituitary herniation and midfacial anomalies *
Author(s) -
Ellyin Fredrick M.,
Potchynok Alan,
Song Chung
Publication year - 1991
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1991.tb03533.x
Subject(s) - medicine , anterior pituitary , pituitary gland , transsphenoidal surgery , pituitary hormones , surgery , hormone , pituitary adenoma , adenoma
Summary. objective We wished to determine whether patients with transsphenoidal pituitary herniation were at risk of developing pituitary failure. design We followed up hypothalamic‐pituitary function annually In patients with midfacial anomalies and pituitary herniation. patients Two patients who had transsphenoldal pituitary herniation and midfacial anomalies were Included and the literature was reviewed. results Both patients became gonadotrophin, TSH and growth hormone‐deficient despite neurosurgical repair. conclusion We conclude that the early diagnosis and neurosurgical repair of transsphenoidal pituitary herniation may prevent central nervous system Infection and rhinorrhoea. Surgical repair may not prevent pituitary failure as was evident in both of our cases. Periodic evaluation of the hypothalamic‐pituitary axis is essential to determine whether early hormonal replacement therapy is necessary.