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Association between autoimmune thyroid disease and Familial Alzheimers disease
Author(s) -
Ewins David L.,
Rossor Martin N.,
Butler Joan,
Rogues Penelope K.,
Mullen Michael J.,
McGregor Alan M.
Publication year - 1991
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1991.tb03502.x
Subject(s) - disease , thyroid disease , thyroid , medicine , thyroglobulin , autoimmune disease , graves' disease , autoantibody , alzheimer's disease , endocrinology , family aggregation , dementia , immunology , antibody
Summary. objective To determine the prevalence of autoimmune thyroid disease in Familial Alzheimer's Disease kindreds and to ascertain whether there is any evidence for genetic linkage between the two conditions. design Retrospective study of Familial Alzheimer's Disease kindreds. patients Seventy affected and unaffected family members from 12 kindreds. measurements Antl‐thyroglobulin and anti‐microsomal autoantibody status was determined using an enzyme‐linked immunosorbent assay. Thyrotrophin levels were determined by an Immunoradiometric assay. results Of the family members, 41.4% had evidence of autoimmune thyroid disease, with significant co‐segregation between the presence of thyroid autoantibodles and the development of Alzheimer's disease ( p <0.01). conclusions This study demonstrates a very high prevalence of autoimmune thyroid disease In Familial Alzhelmer's Disease kindreds and suggests that a genetic factor contributing towards the development of auto‐Immune thyroid disease may be located on chromosome 21 within close proximity to the Familial Alzheimer's Disease gene.