Premium
Effects of ambient glycaemic state on growth hormone responsiveness in insulin‐dependent diabetes
Author(s) -
Ismail I. S.,
Scanlon M. F.,
Peters J. R.
Publication year - 1991
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1991.tb00934.x
Subject(s) - medicine , endocrinology , basal (medicine) , diabetes mellitus , insulin , basal insulin , type 2 diabetes
SUMMARY objective We wished to examine the effects of ambient glycaemla on hypothalamic somatostatlnerglc tone In Insulin‐dependent diabetes mellitus design After 6‐hour periods of either euglycaemla (15 mmol/l) or hyperglycaemia (15 mmol/l), exercise‐induced GH secretion was measured patients Seven insulin dependent diabetics with no evidence of complications were recruited results There was no significant difference between basal GH levels during euglycaemla and hyperglycaemia (5·50 vs 5·53 mU/l). Nor was there a significant difference when mean Δ GH levels (33·9 vs 27·4 mU/l) or mean area under GH curve (2331 vs 4038 mU min/l) during euglycaemia or hyperglycaemia were compared. conclusions We find no evidence therefore to support short‐term effects of ambient glucose concentration on GH responsiveness, and by inference no direct effect of short‐term changes in glycaemic control on hypothalamic release of somatostatln in the aetiology of GH hypersecretion In insulin‐dependent diabetes mellitus