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Comparison of the effects of ANF 99–126 and ANF 103–126 on captopril‐induced renin release in man
Author(s) -
Lang Chim C.,
McMurray John J.,
Moyses Christopher,
Struthers Allan D.
Publication year - 1991
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1991.tb00330.x
Subject(s) - captopril , endocrinology , medicine , plasma renin activity , renin–angiotensin system , supine position , blood pressure , peptide hormone , atrial natriuretic peptide , placebo , chemistry , hormone , alternative medicine , pathology
SUMMARY objective The aim was to examine the effects of atrial natriuretic factor (ANF) 99–126 and ANF 103–126, an N‐terminal shortened analogue of the peptide, on the plasma renin activity response to captopril, an inhibitor of angiotensin‐converting enzyme design Two protocols were performed. In the first protocol, subjects were studied on three occasions. Captopril 25 mg was given and a 60 minute infusion of 5% d ‐glucose (placebo), or ANF 99–126 3 or 10 pmol/kg/min, was administered In a single blind randomized manner. The second protocol was divided in two parallel phases comparing ANF 103–126 either 3 or 10 pmol/kg/min to placebo subjects Thirty‐three salt‐replete healthy male volunteers aged 21–39 years were studied in the supine position measurements Plasma renin activity, plasma ANF 99–126 and ANF 103–126 levels, heart rate and blood pressure were measuredresults Compared to placebo Infusion, the rise in plasma renin activity after captopril was attenuated by ANF 99–126 infusion (from 755% of baseline to 294% by ANF 99–126 3 pmol/kg/min and from 755 to 202% by 10 pmol/kg/min; P >0·03 and P >0·01 respectively). The comparable findings with ANF 103–126 were 492 to 218% (3 pmol/kg/min) and 645 to 364% (10 pmol/kg/min) ( P >0·01 and P >0·01 respectively) . conclusions The results, taken in conjunction with previous findings, suggest that artrial natriuretic factor inhibits in a non‐selective manner the renin response to all secretagotues so far tested In man. The current results also suggest that the anti‐renin action of atrial natriuretic factor does not depend on the first four N‐terminal amino acids of the native peptide