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Effects of antibodies against octreotide in two patients with acromegaly
Author(s) -
Ørskov Hans,
Christensent Stig Engkjær,
Weeket Jargon,
Kaal Andreas,
Harris Alan G.
Publication year - 1991
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1991.tb00311.x
Subject(s) - octreotide , acromegaly , medicine , endocrinology , somatostatin , antibody , immune system , immunology , growth hormone , hormone
Summary Two patients developed specific IgG antibodies against octreotide after 2–3 years’ treatment for acromegaly with this long acting somatostatln analogue. The presence of these antibodies reduced the plasma disappearance rate of total extractable octreotide by 60 and 80% respectively. When compared to that of non‐Immune acromegalic patients, the plasma half‐life of octreotide in these two patients was 300 and 450 vs 110 min in those with no detectable octreotide antibodies. The sole observed con‐sequence of the immunization was a marked prolongation of the Interval of maximum GH Inhibition from a mean of 5 to 8 and 10 h in the two patients described after octreotide injection.