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Role of peripherally infused angiotensin II on the human hypothalamic–pituitary–adrenal axis
Author(s) -
Calogero Aldo E.,
Fornito Marla C.,
Aiiffl Antonia,
Vicarl Enzo,
Moncada Marla L.,
Mantero Franco,
Polosa Pietro,
D'Agata Rosario
Publication year - 1991
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1991.tb00291.x
Subject(s) - medicine , endocrinology , vasopressin , aldosterone , angiotensin ii , blood pressure , hormone , renin–angiotensin system , peptide hormone , arginine , chemistry , amino acid , biochemistry
Summary Although angiotensin II (All), a potent vasoconstrictor agent, has been reported to stimulate the hypothalamicpituitary‐adrenal (HPA) axis of laboratory animals, Its role In the regulation of this axis In humans appears to be controversial. To examine this question, All (Val5‐All amide) was Infused Intravenously Into 19 male normal volunteers at the doses of 0, 1, 3·3 and 10 ng/kg/mln for 30 min. All had no effect on plasma ACTH, cortical, corticotrophin‐releasing hormone, arginine vasopressin, and atrial natriuretic factor concentrations, nor did it increase systolic or diastolic arterial blood pressure. On the other hand, All caused a dose‐dependent Increase of plasma aldosterone concentrations, suggesting that the doses and the mode of All Infusion were effective. Thus, our data show that peripherally Infused All has no detectable effect on the HPA axis function in humans, at doses capable of stimulating plasma aldosterone secretion, Its specific target hormone .