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GONADOTROPHIN SECRETION IN THE SECOND HALF OF THE MENSTRUAL CYCLE: A COMPARISON OF WOMEN WITH NORMAL CYCLES, LUTEAL PHASE DEFECTS AND DISTURBED FOLLICULAR DEVELOPMENT
Author(s) -
SCHWEIGER ULRICH,
TUSCHL REINHARD,
BROOCKS ANDREAS,
PIRKE KARLMARTIN
Publication year - 1990
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1990.tb03746.x
Subject(s) - luteal phase , follicular phase , endocrinology , medicine , menstrual cycle , luteinizing hormone , secretion , pulsatile flow , estrogen , gonadotropin , corpus luteum , biology , ovary , hormone , chemistry
SUMMARY In order to study the relationship between episodic gonadotrophin secretion and alterations of ovarian hormone secretion, we examined women with normal menstrual cycles ( n = 26), luteal phase defects ( n = 10) or disturbed follicular oestradiol secretion ( n = 8) as established by daily (except weekends) determinations of oestradiol and progesterone. Pulsatile gonadotrophin secretion was studied during the luteal phase or the second half of the menstrual cycle sampling at IS min intervals for 12 h. LH and FSH mean concentrations and LH pulse frequency were significantly ( P <0.01) increased in the group with disturbed follicular development in the presence of decreased oestradiol (E2) and progesterone (P4) levels. In women with luteal phase defects mean LH and FSH concentrations and pulsatile LH secretion showed a nonsignificant trend to lower values in the presence of significantly decreased P4 concentrations during the luteal phase.