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EFFECT OF ORAL GLUCOSE ON THE LATE GROWTH HORMONE RISE AND GROWTH HORMONE RESPONSES TO GHRH IN NORMAL SUBJECTS
Author(s) -
VALCAVI R.,
ZINI M.,
DIEGUEZ C.,
PORTIOLI Í.,
SCANLON M. F.
Publication year - 1990
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1990.tb00895.x
Subject(s) - endocrinology , medicine , growth hormone , hormone , growth hormone–releasing hormone
SUMMARY A late rise in serum GH occurs 3‐5 h following oral glucose in man. In order to investigate the mechanisms through which this occurs we have studied the late GH rise after oral glucose during administration of a supramaximal dose of GHRH. In eight normal subjects, oral glucose (100 g) greatly enhanced the GH responses to a supramaximal dose of GHRH (50 μg bolus, followed immediately by 100 μg/h infusion for 3 h) given 3.5 h after the glucose. GH peak (mean±SEM) elicited by GHRH (bolus + infusion) rose from 55.2±20.4 to 133.4±29.6 mU/1 (P< 0.02) after glucose pretreatment. In conclusion, it is likely that the late rise in GH secretion induced by oral glucose occurs via a non‐GHRH‐dependent mechanism. These data are consistent with the hypothesis that the delayed GH response to glucose is a consequence of reduced release of somatostatin from the hypothalamus.