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THYROID FUNCTION IN PATIENTS WITH MYOTONIC DYSTROPHY
Author(s) -
FUKAZAWA HIROSHI,
SAKURADA TOSHIRO,
YOSHIDA KATSUMI,
KAISE NOBUKO,
KAISE KAZURO,
NOMURA TAKASHI,
YAMAMOTO MAKIKO,
SAITO SHINTARO,
TAKASE SADAO,
YOSHINAGA KAORU
Publication year - 1990
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1990.tb00889.x
Subject(s) - medicine , endocrinology , euthyroid , myotonic dystrophy , thyroglobulin , thyroid function , thyroid , thyroiditis
SUMMARY In order to investigate endocrine disturbances in patients with myotonic dystrophy (MD), 12 patients and 20 normal controls were studied. All patients were clinically euthyroid and there were no significant differences between circulating levels (mean±SD) of T 4 (114.7±26.8 vs 129.9± 28.3 nmol/l), FT 4 (16.6±4.5 vs 18.4±3.8 pmol/l), T 3 (1.61±0.29 vs 1.86±0.33 pmol/l), TSH (2.7±1.3 vs 2.4±1.4 mU/l), TBG (26.7±5.5 vs 27.6±4.9 mg/l), T 4 /T 3 (84.3±18.4 vs 82.1±15.3), and FT 4 /FT 3 (0.28±0.05 vs 0.33±0.08). Serum FT 3 (4.3±1.4 pmol/l) in patients were significantly lower than those (5.3±0.9 pmol/l) in normal controls (P<0.02). Thyroidal 131 I‐uptakes (8.7±4.3%) in patients were significantly lower than those (25.8±7.4%) in controls ( P <0.01). The mean maximal TSH responses following TRH stimulation were significantly less in patients with MD (11.4±4.5 vs 17.0±6.2 mU/l; P<0.02). Neither circulating thyroid microsomal nor thyroglobulin antibodies were detectable in the 11 patients tested. Serum thyroglobulin concentrations were within the normal range in all patients but one. In conclusion, it is suggested that normal levels of serum T 4 , T 3 , FT 4 , TSH, TBG, T 4 /T 3 and FT 4 /FT 3 , slight but significant decrease of serum FT 3 , reduced TSH response to TRH and a decrease of thyroidal radioiodine uptake might be due to a slight functional failure of TSH secretion in patients with myotonic dystrophy.