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THE LOSS OF CIRCADIAN RHYTHM FOR INTACT PARATHYROID HORMONE AND NEPHROGENOUS CYCLIC AMP IN PATIENTS WITH PRIMARY HYPERPARATHYROIDISM
Author(s) -
LOGUE F. C.,
FRASER W. D.,
GALLACHER S. J.,
CAMERON D. A.,
O'REILLY D. St J.,
BEASTALL G. H.,
PATEL U.,
BOYLE I. T.
Publication year - 1990
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1990.tb00888.x
Subject(s) - endocrinology , medicine , primary hyperparathyroidism , parathyroid hormone , circadian rhythm , hyperparathyroidism , calcium
SUMMARY The measurement of serum intact parathyroid hormone (PTH) (1‐84) over a 24‐h period has shown the existence of a circadian rhythm in normal males which is absent in patients with primary hyperparathyroidism. The physiological significance of this observation is reflected in the presence of parallel changes in nephrogenous cyclic adenosine monophosphate (N‐cAMP) in normals which are also absent in primary hyperparathyroidism. Serum calcium, adjusted for variations in albumin concentrations, showed a transient fall in normal subjects prior to the nocturnal rise in PTH (1‐84). A similar transient fall in serum adjusted calcium was observed in the hyperparathyroid patients. Serum phosphate showed a circadian rhythm in normal subjects, and an attenuated rhythm persisted in primary hyperparathyroidism. These data suggest that both ionic factors and higher centres play important roles in the fine control of PTH (1‐84) secretion.