Premium
EFFECTS OF CALCITONIN ON GH RESPONSE TO PYRIDOSTIGMINE IN COMBINATION WITH hGHRH (1–29) NH 2 IN NORMAL ADULT SUBJECTS
Author(s) -
GIUSTINA ANDREA,
BODINI CORRADO,
BOSSONI SIMONETTA,
DOGA MAURO,
GIRELLI ANGELA,
PIZZOCOLO GIUSEPPE,
WEHRENBERG WILLIAM B.
Publication year - 1990
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1990.tb00502.x
Subject(s) - pyridostigmine , endocrinology , medicine , somatostatin , growth hormone–releasing hormone , calcitonin , peptide hormone , neuropeptide , acetylcholinesterase inhibitor , hormone , biology , growth hormone , acetylcholinesterase , receptor , enzyme , biochemistry , myasthenia gravis
SUMMARY Studies in man demonstrated that salmon calcitonin (sCT) administration blunts the pituitary GH response to GH‐releasing hormone (GHRH). However, the mechanisms underlying this inhibitory action of CT in man are unclear. Pyridostigmine (PD), an acetylcholinesterase inhibitor, is hypothesized to enhance the GH response to GHRH in normal subjects probably via a decrease in the somatostatinergic tone. The aim of the present study was to investigate the mechanism of the inhibitory action of sCT on the GH response to human GHRH (1–29) NH 2 by concomitant PD administration in normal humans. The GH response to GHRH was significantly suppressed by prior administration of sCT. Pretreatment of subjects with PD significantly enhanced the GH response to GHRH but did not alter the inhibitory actions of sCT. We conclude that sCT is able to inhibit GHRH‐stimulated GH secretion in man without influencing the hypothalamic somatostatinergic tone.