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HLA ANTIGENS IN ASIAN INDIAN PATIENTS WITH Graves'DISEASE
Author(s) -
TANDON N.,
MEHRA N. K.,
TANEJA V.,
VAIDYA M. C.,
KOCHUPILLAI N.
Publication year - 1990
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1990.tb00461.x
Subject(s) - linkage disequilibrium , human leukocyte antigen , haplotype , disease , medicine , immunology , graves' disease , population , antigen , biology , genetics , allele , gene , environmental health
SUMMARY A study of 57 Asian Indian patients with Graves'disease revealed a significant increase in the frequency of HLA‐DQW2 (61.4%) as compared to the control population (22.6%) giving a relative risk of 5.4. Less prominent but statistically significant increase in the frequency of HLA‐A10 (29.8% patients as opposed to 10.5% controls) and HLA‐B8 (28.1% patients as opposed to 8.7% controls) was also observed. Further, patients carrying the phenotypes HLA‐A10 and HLA‐B8 were more prone to develop the disease at a younger age. Two HLA haplotypes, namely A10‐B8 and B8‐DR3, were found in significant linkage disequilibrium in our patients with Graves'disease. Patients carrying these haplotypes also had a tendency to develop the disease at an earlier age.