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LEUCOCYTE SODIUM CONTENT AND SODIUM PUMP ACTIVITY IN OVERWEIGHT AND LEAN HYPERTENSIVES
Author(s) -
NG L. L.,
HARKER M.,
ABEL E. D.
Publication year - 1989
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1989.tb03741.x
Subject(s) - overweight , medicine , endocrinology , sodium , ouabain , chemistry , blood pressure , body mass index , organic chemistry
SUMMARY Leucocyte sodium content and sodium pump activity was studied in overweight and lean hypertensive subjects and normotensive controls, all in the fasting state. In lean subjects (body mass index < 27 kg m −2 ), hypertensives did not have altered leucocyte sodium content or pump activity. In the overweight (mostly obese) subjects, the leucocyte sodium content was higher in hypertensive than in normotensive subjects (median (range) 56.1 (42.0–84.1) vs 320 (18.2–59.4) mmol kg −1 , P < 0.001). This raised sodium content in overweight hypertensives was associated with a lower (ouabain‐sensitive) 22 Na efflux rate constant (2.25 (1.15–3.01) vs 2.64 (1.98–3.61) h −1 , P < 0.05) and a higher passive (or ouabain‐insensitive) 22 Na efflux rate constant (0.90 (0.53–1.18) vs 0.63 (0.21–1.09) h −1 , ( P < 0.01). The systolic and diastolic blood pressures were significantly correlated to intracellular Na + in the overweight group ( r =0.41 and 0.56, P < 0.02 and 0.001 respectively). Thus, hypertension in the overweight subjects is associated with accumulation of intracellular sodium that may be due to abnormalities of the active sodium pump, though changes in ouabain‐insensitive mechanisms also occur.