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CHOLINERGIC BLOCKADE WITH PIRENZEPINE IMPROVES CARBOHYDRATE TOLERANCE AND ABOLISHES THE GH RESPONSE TO MEALS IN NORMAL SUBJECTS
Author(s) -
PAGE M. D.,
BEVAN J. S.,
DIEGUEZ C.,
PETERS J. R.,
SCANLON M. F
Publication year - 1989
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1989.tb01423.x
Subject(s) - pirenzepine , endocrinology , medicine , blockade , cholinergic , carbohydrate , atropine , muscarinic acetylcholine receptor , chemistry , receptor
SUMMARY Pretreatment of normal male volunteers with the cholinergic muscarinic receptor‐blocking drug pirenzepine (200 mg p.o.) abolishes the delayed GH response to a meal stimulus. In addition, the glycaemic and insulin responses to meals are significantly reduced following this dose of pirenzepine. The data suggest that the effect of pirenzepine on the glucose response to meals is at least partly independent of the inhibition of GH release. Our findings are of relevance to the further investigation of cholinergic muscarinic antagonist in diabetes mellitus.