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URINARY GROWTH HORMONE DURING PUBERTY IN NORMAL AND DIABETIC CHILDREN
Author(s) -
EDGE J. A.,
HOURD P.,
EDWARDS R.,
DUNGER D. B.
Publication year - 1989
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1989.tb00440.x
Subject(s) - endocrinology , medicine , urine , urinary system , excretion , immunoradiometric assay , precocious puberty , hormone , radioimmunoassay
SUMMARY The measurement of GH in urine may have many clinical applications, particularly in childhood. We have used a highly sensitive direct immunoradiometric assay to examine urinary GH excretion in children during puberty. Fifty‐five healthy schoolchildren collected timed overnight urine samples. A further 36 children (15 normal, six of short stature and 15 diabetic) collected urine samples during a total of 50 ovenight plasma GH secretory profiles (15‐min sampling). Overnight urinary GH excretion increased during puberty, with a peak at breast stage 2 in girls, and genital stage 4 in boys, before declining at stage 5. There was a positive correlation ( r = 0.57, p = 0.003) with height velocity in girls, but not in boys. At each puberty stage except 2, the diabetics excreted more urinary GH than the normal children. There was a highly significant correlation ( r = 0.79, p <50.001) between mean overnight plasma GH concentrations and urinary GH excretion, suggesting that the latter accurately reflects physiological GH secretion.