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OSMOREGULATION OF VASOPRESSIN SECRETION AND THIRST IN CYCLICAL OEDEMA
Author(s) -
THOMPSON C. J.,
BURD J. M.,
BAYLIS P. H.
Publication year - 1988
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1988.tb03854.x
Subject(s) - vasopressin , medicine , plasma osmolality , endocrinology , luteal phase , thirst , osmoregulation , hypertonic saline , follicular phase , arginine , basal (medicine) , chemistry , biology , insulin , amino acid , ecology , biochemistry , salinity
SUMMARY Osmoregulation of vasopressin release and thirst was studied in the mid‐follicular and mid‐luteal phases of the menstrual cycle of five patients with cyclical oedema defined by peripheral oedema and weight gain (> 30 kg) manifest in two consecutive luteal phases. Results are compared to those already obtained in eight healthy women. In the patients, basal plasma osmolality in the mid‐luteal phase was significantly lower than in the mid‐follicular periods (patients, 283 ± 1, 287 ± 1 mOsmol/kg, respectively, mean ± SEM, P < 0.05; controls, 282 ± 1, 286 ± 1 mOsmol/kg, respectively, P < 0.05). Plasma osmolality (pOsm) and plasma arginine vasopressin (pAVP) were measured during hypertonic (850 mmol/l) saline infusion in both phases of the cycle; linear regression analyses of these data gave the following mean regression equations, (i) mid‐follicular, pAVP=0.55 (pOsm — 285), r=0.94 and (ii) mid‐luteal, pAVP=0.42 (pOsm —281), r =0.93. The abscissal intercept was significantly different ( P < 0.025). Osmotic threshold for severe thirst onset was lower in the mid‐luteal phase compared to the mid‐follicular value (296 ± 1, 299 ± 1 mOsmol/kg, respectively, P < 0.01). Basal data and results of thirst onset and theoretical threshold for vasopressin release in response to osmotic stimulation obtained in the patients were similar to healthy control women. We conclude that osmoregulation in cyclical oedema is normal.