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RADIOIMMUNOASSAY ARTIFACT ASSOCIATED WITH CIRCULATING ANTI‐RABBIT ANTIBODIES
Author(s) -
JEFFCOATE W. J.,
SELBY C.,
POWELL R. J.
Publication year - 1988
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1988.tb01201.x
Subject(s) - radioimmunoassay , endocrinology , medicine , antibody , rabbit (cipher) , artifact (error) , chemistry , biology , immunology , neuroscience , statistics , mathematics
SUMMARY A 30 year old woman presenting with infertility was found to have elevated serum immunoreactive prolactin, TSH and total T3. These findings were eventually attributed to assay artifact when she was shown to have anti‐rabbit antibodies in her serum. The possibility of laboratory artifact should be considered in clinical practice when abnormal immunoassay results are unsupported by clinical or radiographic data.