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PLASMA AND CYST FLUID LEVELS OF A5 AND A4 STEROID HORMONES IN WOMEN WITH GROSS CYSTIC BREAST DISEASE
Author(s) -
INAUDI P.,
BERNABEI A.,
GIOFFRÉ W.,
FRANCHI F.,
MAZZULLO G.,
LEO V.,
D'ANTO.
Publication year - 1987
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1987.tb02946.x
Subject(s) - androstenedione , medicine , endocrinology , luteal phase , cyst , hormone , steroid , follicular fluid , follicular cyst , ovarian cyst , chemistry , biology , ovary , androgen , pathology , oocyte , embryo , microbiology and biotechnology
SUMMARY Δ5 and Δ4 steroid levels were studied in the plasma and cyst fluid of women with gross cystic breast disease (GCBD). In luteal phase a significant increase in plasma levels (mean + SEM) of DHA (11.2 ± 2.4 ng/ml), DHAS (1.45 ± 0.6 fig/ ml) and Cortisol 277 ± 15.7 ng/ml) was found; in follicular phase the mean levels were 4.09 ± 0.47 ng/ml for DHA, 0.65 ± 0.08 μg /ml for DHAS and 190 ± 46.3 μg/ml for Cortisol. The DHA/DHAS and cortisol/androstenedione ratios were significantly higher in the plasma and lower in the cyst fluid of GCBD patients, than in the plasma of controls; the androstenedione/DHA ratio was higher in the cyst fluid than in the plasma of controls. The hormonal situation of the GCBD patients thus differed from that of the controls both in the plasma and cyst fluid, particularly as regards the Δ5 steroids.