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NON‐ADENOMATOUS INAPPROPRIATE TSH HYPERSECRETION AND EUTHYROIDISM REQUIRES NO TREATMENT
Author(s) -
HUGHES I. A.,
ICHIKAWA K.,
DEGROOT L. J.,
JOHN R.,
JONES M. K.,
HALL R.,
SCANLON M. F.
Publication year - 1987
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1987.tb01176.x
Subject(s) - endocrinology , medicine , euthyroid , antithyroid drugs , thyroid , secretion , receptor , antithyroid agent , nuclear receptor , graves' disease , biology , transcription factor , biochemistry , gene
SUMMARY The syndrome of inappropriate TSH secretion is described in a euthyroid girl and her father. Based on nuclear T 3 binding studies in fibroblasts, generalized tissue resistance was associated with a lower binding affinity for T 3 in nuclear extracts suggestive of a structurally abnormal receptor for T 3 . Early recognition of the syndrome and observation of the short‐term response to thyroid medication prevented unnecessary trials of antithyroid medication and later radical ablative thyroid treatment.