Premium
THE EFFECT OF GLUCOCORTICOIDS ON CORTICOSTEROID BINDING GLOBULIN
Author(s) -
SCHLECHTE J. A.,
HAMILTON D.
Publication year - 1987
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1987.tb01145.x
Subject(s) - transcortin , endocrinology , medicine , glucocorticoid , endogeny , globulin , corticosteroid , glucocorticoid receptor , binding protein , hydrocortisone , chemistry , biochemistry , gene
SUMMARY To evaluate the effect of glucocorticoids on corticosteroid binding globulin (CBG), we measured the binding capacity and binding affinity of Cortisol for CBG in normal subjects, patients receiving glucocorticoids and patients with Cushing's syndrome. Normal subjects had a mean binding capacity of 3.8 (±SD 0.7) ± 10 ‐7 mol/l and mean binding affinity of 1.96 ± 0.48 ± 10 ‐8 M. Patients with Cushing's syndrome had a 40% decrease in binding capacity (2.3±0.4 ± 10 ‐7 mol/l) compared to control subjects and significantly lower mean binding capacity than patients receiving pharmacological (2.9 ± 0.6 ± 10 ‐7 mol/l) and physiological doses of glucocorticoids (3.4 ± 0.6 ± 10 ‐7 mol/l) ( P = 0.05 one‐way analysis of variance). Patients with endogenous Cortisol excess also had significantly lower mean binding affinity (1.54 ± 0.37 ± 10 ‐8 M) than normal subjects and glucocorticoid treated subjects. These changes suggest that both endogenous and exogenous glucocorticoids can modulate circulating levels of CBG and may have important implications for patients receiving steroid therapy.