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LONG‐TERM SUPPRESSION OF A TESTOSTERONE‐PRODUCING OVARIAN TUMOUR BY OESTROGEN/PROGESTOGEN THERAPY
Author(s) -
DRIFE J. O.,
O'MALLEY B. P.,
ROSENTHAL F. D.
Publication year - 1987
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1987.tb00847.x
Subject(s) - progestogen , testosterone (patch) , medicine , hirsutism , endocrinology , leydig cell , ovary , hormone , luteinizing hormone , polycystic ovary , insulin , insulin resistance
SUMMARY A 44‐year‐old lady presenting with hirsutism was found to have a testosterone‐secreting Leydig cell tumour of the right ovary. Serum testosterone levels were adequately suppressed for 8 years by combined oestrogen/progestogen preparation (Microgynon 30, Schering, West Sussex). The fall in gonadotrophin and testosterone levels during therapy and their rise after stopping therapy suggests that the tumour was gonadotrophin dependent.