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IMMUNOHISTOCHEMICAL STUDY OF CALCITONIN GENE‐RELATED PEPTIDE IN HUMAN MEDULLARY CARCINOMA AND C CELL HYPERPLASIA
Author(s) -
WILLIAMS E. D.,
PONDER B. J.,
CRAIG R. K.
Publication year - 1987
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1987.tb00845.x
Subject(s) - calcitonin , calcitonin gene related peptide , immunohistochemistry , medullary carcinoma , medicine , endocrinology , hyperplasia , medullary cavity , pathology , neuropeptide , receptor , thyroid carcinoma , thyroid
SUMMARY The distribution of calcitonin and calcitonin gene‐related peptide (CGRP) has been studied by immunohistochemistry in normal, hyperplastic and neoplastic C cells. Fewer normal C cells contained immunoreactive CGRP than calcitonin, though both peptides can be co‐expressed by a single cell. In the hyperplastic C cells that accompany familial medullary carcinoma immunohistochemistry was strongly and diffusely positive for both CGRP and calcitonin. In contrast, in medullary carcinoma, whether sporadic or familial, little CGRP was identified; often only a few strongly positive cells were found in a negative background, while immunoreactive calcitonin was commonly present in large amounts. The findings suggest that CGRP immunohistochemistry may be of value in identifying hyperplastic C cells, and that CGRP levels should be studied in medullary carcinoma families.