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LITHIUM INHIBITS THE ACTION OF FLUDROCORTISONE ON THE KIDNEY
Author(s) -
STEWART P. M.,
GRIEVE J.,
NAIRN I. M.,
PADFIELD P. L.,
EDWARDS C. R. W.
Publication year - 1987
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1987.tb00839.x
Subject(s) - fludrocortisone , endocrinology , mineralocorticoid , medicine , hypoaldosteronism , plasma renin activity , lithium carbonate , aldosterone , lithium (medication) , sodium , hydrocortisone , chemistry , renin–angiotensin system , ion , blood pressure , organic chemistry , ionic bonding
SUMMARY A patient with autoimmune Addison's disease treated with hydrocortisone and fludrocortisone became mineralocorticoid‐deficient whilst taking lithium carbonate for a bipolar illness. During an in‐patient metabolic balance study she required 1.0 mg fludrocortisone daily and dietary sodium supplementation to make plasma renin activity and serum potassium normal, and to abolish postural hypotension. We present data to suggest that lithium carbonate inhibits the action of fludrocortisone on the distal renal tubule.