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EVIDENCE FOR GONADAL DESENSITIZATION AFTER PULSATILE THERAPY IN WOMEN WITH AMENORRHOEA?
Author(s) -
GLASIER A.,
BAIRD D. T.,
McNEILLY A. S.
Publication year - 1987
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1987.tb00801.x
Subject(s) - hypogonadotrophic hypogonadism , medicine , endocrinology , hyperprolactinaemia , ovulation , menstrual cycle , amenorrhea , desensitization (medicine) , pulsatile flow , gonadotropin , blood sampling , menotropins , pregnancy , hormone , ovulation induction , prolactin , biology , receptor , genetics
SUMMARY Sixteen women with primary and secondary amenorrhoea were treated with pulsatile GnRH administered subcutaneously. Ovulation was successfully induced in 6/8 women with hypogonadotrophic hypogonadism; and in 2/2 women with idiopathic hyperprolactinaemia; but in only 3/6 women with amenorrhoea associated with an elevated LH:FSH ratio. Using serial blood sampling, we were unable to demonstrate the establishment of a physiological pattern of gonadotrophin secretion in the presence of an apparently normal menstrual cycle. Nor did we observe a consistent relationship between injection of GnRH and the resultant gonadotrophin response. A reduction or total cessation of both pituitary and gonadal sensitivity to GnRH was observed in four women. Possible reasons for these findings are discussed.