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THE PLASMA ARGININE VASOPRESSIN RESPONSE TO INSULIN‐INDUCED HYPOGLYCAEMIA IN CHILDREN WITH SHORT STATURE IS RELATED TO AGE AND THE ONSET OF PUBERTY
Author(s) -
SECKL J. R.,
DUNGER D. B.,
HUEN K.,
LIGHTMAN S. L.
Publication year - 1987
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1987.tb00792.x
Subject(s) - medicine , endocrinology , vasopressin , insulin , short stature , arginine , diabetes insipidus , bone age , biology , biochemistry , amino acid
SUMMARY The plasma arginine vasopressin (AVP) response to insulin‐induced hypoglycaemia was investigated in 27 children with short stature. None had diabetes insipidus. Six patients were excluded from further analysis because of hypothalamo‐pituitary dysfunction. Of the remainder, 14 were prepubertal (Tanner 1) and seven were pubertal (Tanner 2–4). Both groups had similar height velocity retardation. There was a significant rise of AVP of 3.4±1.3 pmol/1 at 30 min in the pubertal group ( P < 0.05) but no significant change in prepubertal patients. There was a significant relationship between chronological age and AVP response 30 min after insulin ( r = 0.45, P < 0.05) and a closer correlation between bone age and AVP response ( r = 0.62, P < 0.01). The data suggest that insulin‐induced hypoglycaemia does not reliably stimulate AVP secretion in children and that this response is related to age and pubertal stage.