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SUBACUTE THYROIDITIS: ACTIVATED HLA‐DR AND INTERFERON‐γ EXPRESSING T CYTOTOXIC/SUPPRESSOR CELLS IN THYROID TISSUE AND PERIPHERAL BLOOD
Author(s) -
KARLSSON F. A.,
TÖTTERMAN T. H.,
JANSSON R.
Publication year - 1986
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1986.tb03600.x
Subject(s) - cytotoxic t cell , medicine , thyroiditis , subacute thyroiditis , immunology , thyroid , major histocompatibility complex , endocrinology , antigen , biology , in vitro , biochemistry
SUMMARY Using a two‐colour direct immunofluorescence staining technique, we investigated activated HLA‐DR‐expressing T helper and T cytotoxic/suppressor cells in peripheral blood of six patients with subacute thyroiditis at referral and at follow‐up and in blood from 20 controls. In three of the patients, thyroid fine‐needle aspirates were examined as well. At referral, all patients had elevated blood levels of activated T helper and T cytotoxic/suppressor cells 2 (2–4)%, median and range, vs 0 (0–2)%, P < 0.001 and 12.5 (2–24)%, vs 0 (0–1)% P < 0001). At follow‐up, the activated proportion of T helper cells had become normal whereas some activated T cytotoxic/suppressor cells remained, 7 (0–8)%. No significant changes in total T cell number were detected when data at referral and at follow‐up were compared. In thyroid aspirates, HLA‐DR expressing thyrocytes were observed; the total proportion of T cytotoxic/suppressor cells was elevated (70% compared with 35% in blood) and 70% of the T cytotoxic/suppressor cells were HLA‐DR + . Furthermore, 55% of the thyroid‐infiltrating lymphoid cells were positive for interferon (IFN‐γ + ). The finding of activated T cytotoxic/suppressor cells in the blood and thyroid tissue in subacute thyroiditis is consistent with a viral aetiology. Furthermore, intrathyroidal IFN‐γ + lymphocytes are likely to contribute to expression of major histocompatibility complex (MHC) class II antigens on thyrocytes. No autoantibodies, however, were detected, which suggests that aberrant expression of MHC class II molecules alone is not sufficient to provoke an autoimmune response.