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AUTONOMOUS OVARIAN HYPERFUNCTION FOLLOWED BY GONADOTROPHIN‐DEPENDENT PUBERTY IN McCUNE‐ALBRIGHT SYNDROME
Author(s) -
KAUFMAN FRANCINE RATNER,
COSTIN GERTRUDE,
REID BARBARA S.
Publication year - 1986
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1986.tb03263.x
Subject(s) - mccune–albright syndrome , endocrinology , medicine , precocious puberty , hormone
SUMMARY A 5‐year‐old girl with the McCune‐Albright syndrome presented with precocious puberty secondary to autonomously functioning ovarian cysts, followed by true central puberty. Progression from gonadotrophin‐independent to gonadotrophin‐dependent precocious puberty may occur from elevated sex steroid levels leading to the early maturation of the hypothalamic‐pituitary axis.