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FAMILIAL HYPOPITUITARISM ASSOCIATED WITH AN ENLARGED PITUITARY FOSSA AND AN EMPTY SELLA
Author(s) -
WHITE M. C.,
CHAHAL P.,
BANKS L.,
JOPLIN G. F.
Publication year - 1986
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1986.tb03255.x
Subject(s) - hypopituitarism , endocrinology , anterior pituitary , medicine , short stature , involution (esoterism) , pituitary hormones , empty sella syndrome , pituitary gland , hormone , biology , consciousness , neuroscience
SUMMARY We report an 8‐year follow‐up of three sisters born of a consanguineous marriage and who originally presented with short stature and enlarged pituitary fossa. All have shown progressive failure of anterior pituitary hormone function. In addition, the two eldest sisters were eventually found to have an empty sella while the youngest, who initially showed an enhancing intrasellar mass consistent with a tumour, later showed an empty sella. A familial pituitary tumour developing early in childhood but subsequently undergoing involution could account for these findings.