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RELATIONSHIPS BETWEEN THE CHARACTERISTICS OF ENDOGENOUS LUTEINIZING HORMONE SURGE AND THE DEGREE OF OVARIAN HYPERSTIMULATION DURING SUPEROVULATION INDUCTION IN WOMEN
Author(s) -
MESSINIS I. E.,
TEMPLETON A.,
BAIRD D. T.
Publication year - 1986
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1986.tb01705.x
Subject(s) - endocrinology , medicine , luteinizing hormone , controlled ovarian hyperstimulation , follicular phase , gonadotropin , clomifene , pulsatile flow , menotropins , in vitro fertilisation , endogeny , ovarian hyperstimulation syndrome , ovulation induction , biology , hormone , ovulation , embryo , microbiology and biotechnology
SUMMARY Ovarian hyperstimulation was induced in 17 normally cycling women undergoing in‐vitro fertilization (IVF) and embryo transfer with clomiphene (9 cycles), clomiphene followed by pulsatile hMG (12 cycles) or clomiphene followed by pulsatile FSH (11 cycles). Hyperstimulation was greater with the combined treatments than with clomiphene alone. In all 32 cycles an endogenous LH surge occurred. The peak values and the duration of the LH surge showed significant negative correlations with the plasma oestradiol levels, the number of the follicles and the total follicular fluid volume aspirated at laparoscopy. We suggest that during superovulation induction for IVF, the endogenous LH surge is attenuated by factors which are related to the degree of ovarian hyperstimulation.