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HIGH ACTIVITY OF CYCLIC 3′,5′‐NUCLEOTIDE PHOSPHODIESTERASE IN SERA OF PATIENT WITH PHAEOCHROMOCYTOMA
Author(s) -
NAKAI AKIRA,
NAGASAKA AKIO,
OHYAMA TAKAKO,
AONO TOSHIHIRO,
IWASE KATSUMI,
HASEGAWA HARUHIKO,
HAYAMI SHIRO,
HIDAKA HIROYOSHI,
TANAKA TOSHIO,
NIINOMI MITSURO,
NIHEI NORIYUKI,
NAKAGAWA HIFUMI,
OHTANI SUSUMU,
MIYAKAWA SHUICHI,
KAWASE KYOHEI
Publication year - 1986
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1986.tb01645.x
Subject(s) - medicine , endocrinology , phosphodiesterase , glucagon , cyclic nucleotide , acromegaly , cyclic nucleotide phosphodiesterase , cyclic gmp , cyclase , enzyme , nucleotide , chemistry , hormone , biochemistry , receptor , growth hormone , nitric oxide , gene
SUMMARY Our previous observations that serum cyclic 3′,5′‐nucleotide phosphodiesterase activity varied in thyroid disorders and was positively correlated with thyroid function stimulated us to investigate the phosphodiesterase levels in sera of patients with pituitary and adrenal disorders, and the response to glucagon in normal subjects. Both serum cyclic AMP phosphodiesterase (cyclic AMP‐PDE) and cyclic GMP phosphodiesterase (cyclic GMP‐PDE) activities were measured at a low substrate concentration. Serum cyclic AMP‐PDE activity was elevated in five patients with phaeochromocytoma and was not elevated in patients with Cushing's syndrome or acromegaly, compared to the level in normal subjects. Increased enzyme activities returned to normal after resection of the tumours. Intramuscular injection of glucagon to five healthy subjects elevated cyclic AMP levels and cyclic AMP‐PDE activity in plasma. These results imply that the increased cyclic AMP level by the activation of cyclase may have induced cyclic AMP‐PDE in the target organ and the soluble cyclic AMP‐PDE may leak into blood vessels from target organs.