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NORMAL CIRCULATING IMMUNOREACTIVE GROWTH HORMONE RELEASING FACTOR (hGRF) CONCENTRATIONS IN PATIENTS WITH FUNCTIONAL HYPOTHALAMIC hGRF DEFICIENCY
Author(s) -
SOPWITH A. M.,
PENNY ELIZABETH S.,
GROSSMAN A.,
SAVAGE M. O.,
BESSER G. M.,
REES LESLEY H.
Publication year - 1986
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1986.tb01643.x
Subject(s) - endocrinology , medicine , radioimmunoassay , biology , human growth hormone , hormone , hypothalamus , growth hormone
SUMMARY Using a highly specific radioimmunoassay we have measured the concentrations of human growth hormone releasing factor (ir‐hGRF) in the peripheral circulation of six individuals with acquired hypothalamic hGRF deficiency. Despite their hypothalamic dysfunction venous plasma ir‐hGRF increased normally in every patient after the stimulus of a mixed breakfast, from an average concentration basally of 13.6 ± 6.0pg/ml to a maximum of 29.0 ± 8.4 pg/ml (mean ± SEM) at 120 min. The findings indicate that circulating hGRF is at least in large part extrahypothalamic in origin, which in turn implies a physiological role for hGRF in the periphery.